You won’t have a problem if you are not working with Azure.
Microsoft focused on Azure after the 2008R2 level.
The main change is the return of WMI structure instead of the RPC structure.
At this point, changes were made to the system for directing to the DC structures installed to Azure. Many features were abandoned because of this, and clients were directed to transfer to Azure.
You can learn more about the version changes here: https://docs.microsoft.com/en-us/windows-server/identity/ad-ds/active-directory-functional-levels.